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March 4, 2024 2024 Power 50

2024 Power 50: 42. John Houston

PHOTO | CONTRIBUTED John Houston, president, CEO and chair of Arvinas.

Arvinas may be one of Connecticut’s most promising clinical-stage life science companies.

The New Haven-based biotech is led by John Houston, who has helped the company reach several important milestones.

With a recent $350 million fundraise, Houston said the publicly traded company is now financed through at least 2027 to pursue bringing its cancer-fighting drugs to market.

Arvinas is working on treatments for breast and prostate cancer. It has been focused on creating drugs that harness the body’s natural protein disposal system to remove disease-causing proteins.

Arvinas has an ongoing collaboration with Pfizer to develop and commercialize Vepdegestrant, a breast cancer drug candidate in phase 3 clinical trials.

Find out who else is in the 2024 Power 50.

Houston said he anticipates data from those ongoing trials by the end of 2024, and if they are positive, the drug could be brought to market as early as next year.

“That’d be very exciting for Arvinas, which would be transitioning from a late-stage development to a commercial company over the next couple of years,” Houston said.

Arvinas also is pursuing a prostate cancer treatment, with phase 3 trials expected to begin in the next year, Houston said.

The company, which has been working out of Science Park and has 450 employees, has leased three floors, or 160,000 square feet of lab and office space in developer Carter Winstanley’s new 101 College St. bioscience tower, which is slated to open in the coming months. The move will more than double Arvinas’ current space.

Houston has over 30 years of industry experience and previously served as the senior vice president of specialty discovery at Bristol Myers Squibb. He also worked at Glaxo Wellcome Research and Development in the U.K., where he served as head of the lead discovery unit.

Find out who else is in the 2024 Power 50.

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